$170.00 – $2,700.00
cannabinoid JWH-018 also known as(1-pentyl-3-(1-naphthoyl) indole), is a synthetic jwh-250 research chemical, and EZRC are the first to stock.
It is an carbazole based cannabinoid that is the carbazole analogue of JWH-018 and so is perfect for researchers in countries where other cannabinoids are controlled. Like chemicals such as THJ-018 and AB-PINACA, it has relatively low in-vitro CB1/CB2 activity but is still interesting for researchers who like to study that type of synthetic cannabinoid.
cannabinoid Scientists can conduct experiments to determine the basic data on the material, such as melting points, and solublities etc. and see how it compares and contrasts with the data from similar chemicals.
EZRC stock EG-018 in the form of a off-white, high purity powder.
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannbinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human
cannabinoid JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2. JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors. JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity
Synthetic jwh-250 Receptor Agonists
By the end of 2011, six major groups of synthetic jwh-250 receptor agonists had been reported: naphthoylindoles (n=74), naphthylmethylindoles (n=9), naphthoylpyrroles (n=32), naphthylmethylindenes (n=3), phenylacetylindoles (n=28) and cyclohexylphenols (n=16) [93,146]. The numbers of compounds known to be bioactive as CB1-receptor agonists are given in brackets. In addition, methanandamide a derivative from anandamide (an endogenous cannabinoid) was described to be active and have increased metabolic stability .
The cross-reactivity of synthetic jwh-250 receptor agonists and their metabolites in urine samples was investigated by Grigoryev et al.  who checked the immunochromatographic test strips ICA-4-MULTI-FACTOR, ICA-MARIJUANA-FACTOR, and ICA-TAD-FACTOR. As expected, none of these tests were able to indicate the consumption of synthetic cannabinoid receptor agonists.
Bioanalytical methods for synthetic jwh-250 receptor agonists have been described for the following matrices: blood , serum [11,17,93,149], urine [11,68,91,150–155], and oral fluid . Sample preparation consisted of simple dilution and centrifugation
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